Africa-Europe partnership to launch historic Phase 3 clinical trial in early pregnancy
In a world first, a global consortium plans to undertake a Phase 3 clinical trial assessing antimalarial medicines in women in their first trimester of pregnancy The trial will evaluate the efficacy, safety, tolerability and cost-effectiveness of antimalarial drugs to treat uncomplicated malaria This pioneering approach challenges the status quo in which pregnant women are typically excluded […]
Re-orienting anti-malarial drug development to better serve pregnant women
Malaria is one of the most serious infectious diseases affecting predominantly low- and middle-income countries, where pregnant women are among the populations at risk. There are limited options to prevent or treat malaria in pregnancy, particularly in the first trimester, and existing ones may not work optimally in areas where the threat of drug resistance […]
Opinion: Malaria clinical research must include pregnant women
Malaria is a dangerous disease. One that, according to the World Health Organization, resulted in 249 million cases and 608,000 deaths in 2022 worldwide. For pregnant women, particularly those in their first trimester, it can cause serious complications, a concern for over 120 million women of childbearing age living in malaria-endemic areas. Malaria in pregnancy can result in maternal and neonatal mortality, miscarriage, […]